On the 17th of November, we conducted a new webinar titled “Effective Trial Design: Clinical Trials in Small Patient Populations”.
Designing and conducting clinical trials in indications with inherently small patient populations, such as rare disease, can be quite difficult. The limited number of patients available for the trials has a direct impact on the difference in clinical outcomes that can be detected between treatment groups. Another challenge is the extended time to recruit the necessary number of patients.
During this webinar, we presented several alternatives for small patient population study design to help overcome these challenges. Some of the designs that we presented can potentially help to minimise the time to final trial conclusion.
What did the participants learn?
- Available options for study design in indications with small patient populations
- Advantages and disadvantages of each design
- How to decide on appropriate design for planned clinical trials
The webinar was conducted by Thomas Zwingers, Statistical Consultant of CROS NT.
Thomas has been working in the clinical trial environment since 1980. He is specialized in statistical analysis and reporting with particular expertise in Adaptive Trial Design. Prior to joining CROS NT, Thomas ran his own biometrics consulting CRO in Germany for over 20 years. During this time, he gained a considerable amount of experience in Dermatology, Respiratory and Oncology studies.
Thomas holds a Master’s degree in Cybernetics from the Technical University of Munich. He is member of numerous international associations, including the Biometric Society, International Society for Clinical Biostatistics and the Society for Clinical Trials. He has written and collaborated on over 100 publications in the pharmaceutical and clinical trial statistics.