Innovations in Clinical Trial Design

On the 9th of April 2020 CROS NT conducted a webinar focused on the use of enrichment designs for reducing placebo response and thereby enhancing signal detection. This webinar described the use of a Sequential Parallel Comparison Design (SPCD) to increase the chance of success of clinical trials, especially trials with possibly high placebo effect. Over time, a progressive increase in placebo response has been observed in controlled clinical trials in psychiatry.

Webinar learning outcomes:

  • Impact of placebo response in clinical trials
  • How the SPCD design improves efficiency of signal detection
  • Statistical analysis of SPCD studies
  • SPCD examples in clinical trials

The webinar was presented by:

  • Dr Maurizio Fava MD – Psychiatrist-in-Chief of Massachusetts General Hospital and Associate Dean for Clinical and Translational Research of Harvard Medical School
  • Dr Tri Tat – Principal Biostatistician of CROS NT